Sequence-Selective 2'-O-Acetyl Modification of RNA Mediated by Duplex Formation with a Reactive Oligonucleotide Probe Incorporating 4-Thio-dT.

We designed and synthesized an oligonucleotide acetylating reagent (Ac-probe) that selectively acetylates the 2'-OH groups of RNA upon forming a duplex with the target RNA. The Ac-probe can be readily prepared via a post-synthetic modification method…

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