Chemical & pharmaceutical bulletinAptamersNucleotideHumansErb-b2 Receptor Tyrosine KinasesLysosomes
Linker Length Optimization of Bispecific DNA Aptamer-Based HER2 Targeting Lysosome-Targeting Chimera (HER2-LYTAC).
Yusei Yoda, Eugen Potaptschuk, Natsumi Ishimori, Yuji Yamada, Yamato Kikkawa, Keisuke Hamada
Published: 202510.1248/cpb.c25-00494
Abstract
Lysosome-targeting chimera (LYTAC) efficiently degrades specific membrane proteins. In a previous study, we synthesized and reported human epidermal growth factor receptor 2 (HER2)-LYTAC (that induces the degradation of HER2 protein using DNA aptamer…
Preview only. Read the full abstract at the source