Chemical & pharmaceutical bulletinAntimicrobial PeptidesFluorescenceLipid BilayersPhospholipidsSpectrometry
In Situ Monitoring of Phospholipid Flip-Flop via Fluorescence Self-quenching.
Hiroyuki Nakao, Yu Maeshiro, Keisuke Ikeda, Minoru Nakano
Published: 202510.1248/cpb.c25-00464
Abstract
Many antimicrobial peptides (AMPs) exert their activity by disrupting the integrity of the bacterial plasma membrane. One of the membrane-disrupting mechanisms of AMPs involves the formation of toroidal pores, composed of α-helices and lipid headgrou…
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