Chemical & pharmaceutical bulletinIndolesCyclizationSulfonamidesMolecular StructureCatalysis
Efficient Synthesis of 8-Membered Fused Indoles via Intramolecular Friedel-Crafts Reaction of N-(2,2-Dimethoxyethyl)sulfonamides.
Kirara Sugiura, Shota Machida, Yoshimi Ichimaru, Koichi Kato, Noa Ohashi, Satsuki Suzuki, Ai Takemoto, Mina Takaoka, Wanchun Jin, Kazuhiko Hayashi, Masanori Imai
Published: 202510.1248/cpb.c25-00202
Abstract
Synthesis of 8-membered rings is one of the most challenging transformations in organic chemistry because of entropic hindrance and ring strain. Azocino[4,3-b]indole frameworks are characterized by fused indole-azocane systems and are vital structura…
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