Biological & pharmaceutical bulletinAnimalsGuinea PigsSodium-Calcium ExchangerAnti-Arrhythmia AgentsHeart Ventricles
Na+/Ca2+ Exchanger-Mediated Negative Inotropy of Na+ Channel Blockers Pilsicainide, Cibenzoline, and Propafenone in Guinea Pig Ventricular Myocardial Tissue Preparations.
Maika Seki, Akane Iinuma, Yuna Shiota, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka
Published: 202610.1248/bpb.b25-00692
Abstract
Involvement of the Na+/Ca2+ exchanger (NCX) in the negative inotropic effects of class I antiarrhythmic drugs, pilsicainide, cibenzoline, and propafenone, was examined in isolated guinea pig ventricular myocardium. The class I antiarrhythmic drugs, a…
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