Biological & pharmaceutical bulletinHumansMutationMaleFemaleThyroid Hormone Resistance Syndrome
Effects of Resmetirom on Resistance to Thyroid Hormone Receptor Mutants: Potential Basis for Therapeutic Applications.
Mana Mitsutani, Hiromi Hano, Mei Yokoyama, Midori Matsushita, Tetsuya Tagami, Kenji Moriyama
Published: 202510.1248/bpb.b25-00513
Abstract
Resistance to thyroid hormone-β (RTHβ) is caused by mutations in thyroid hormone receptors (TRs), with palpitations, tachycardia, and/or goiter being the most frequently reported clinical features. In recent years, several synthetic thyromimetics hav…
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