Downregulation of HepaRG Cell CYP Genes by Hypoxia Inducible Factor Prolyl Hydroxylase (HIF-PH) Inhibitor.

Metabolic enzymes are occasionally downregulated in in vitro induction studies. Recently, HepaRG cells have been used for CYP induction assays instead of human hepatocytes in the early drug discovery stage; however, there is limited information on CY…

Preview only. Read the full abstract at the source