Biological & pharmaceutical bulletinHumansSpheroidsCellularOxygenOxygenases
Effects of Oxygen-Permeable Plates on Cytochrome P450 and Flavin-Containing Monooxygenase in HepaRG Spheroid Cultures.
Naoki Takaoka, Momoka Morita, Jun Takahashi, Katsuhiro Esashika, Shigeru Ohta, Seigo Sanoh
Published: 202610.1248/bpb.b25-00489
Abstract
Three-dimensional (3D) hepatocyte spheroid cultures offer an advanced in vitro model for investigating liver function and drug metabolism; however, oxygen diffusion limitations restrict spheroid size and functionality. In the present study, we develo…
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