Biological & pharmaceutical bulletinAnimalsRabbitsTorsades de PointesPhenethylaminesSulfonamides
Antiarrhythmic Potential of the β-Adrenoceptor Blocker Metoprolol against Dofetilide-Induced Torsades de Pointes in Anesthetized Bradycardic Rabbits.
Satoshi Kawakami, Yuki Ishimaru, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Published: 202610.1248/bpb.b25-00450
Abstract
We have established a proarrhythmic rabbit model of acute atrioventricular block (AVB) with severe bradycardia to detect delayed rectifier K+ channel current (IKr) blocker-induced torsade de pointes (TdP). To better understand the role of β-adrenocep…
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