Biological & pharmaceutical bulletinAnimalsDNA RepairMelanomaExperimentalRadiation Tolerance
P2Y12 Receptor Antagonists Decrease the Radiation Resistance of B16 Melanoma by Suppressing DNA Repair.
Yuma Mizoguchi, Natsuki Mori, Kazuki Kitabatake, Shuhei Ogawa, Fumiaki Uchiumi, Mitsutoshi Tsukimoto
Published: 202510.1248/bpb.b25-00420
Abstract
Radiation therapy exerts its therapeutic effect by killing cells via the induction of DNA double-strand breaks (DSBs) in malignant tumors, but cancer cells can repair damaged DNA, leading to radiation resistance (radioresistance). Therefore, a radios…
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