Annals of surgical oncology
TRIM37 Expression is Associated with Immune Suppression Poor Response to Neoadjuvant Chemotherapy and Worse Survival in ER-Positive/HER2-Negative Breast Cancer.
Junko Tsuchida, Rongrong Wu, Masayuki Nagahashi, John M L Ebos, Takashi Ishikawa, Masafumi Shimoda, Toshifumi Wakai, Kazuaki Takabe
Published: 202510.1245/s10434-025-18764-x
Abstract
BACKGROUND: Tripartite motif-containing 37 (TRIM37) is an E3 ubiquitin ligase that epigenetically silences tumor suppressors in DNA repair, regulates polo-like kinase 4, promotes chromosomal instability, and functions as an oncogenic driver in breast…
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