Journal of cell sciencePaclitaxelInterphaseHumansCytoskeletonCell Nucleus
Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling.
Thomas Hale, Victoria L Hale, Piotr Kolata, Ália Dos Santos, Matteo Allegretti
Published: 202610.1242/jcs.264494
Abstract
Regulation of lamin A/C levels and distribution is crucial for nuclear integrity and mechanotransduction via the linker of nucleoskeleton and cytoskeleton (LINC) complex. Dysregulation of lamin A/C correlates with poor cancer prognosis, and its level…
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