Hyperactive microtubule binding of RP1L1 (R45W) underlies retinal degeneration and is suppressed by glycerol.

Photoreceptors rely on microtubule (MT)-based transport within the connecting cilium to maintain cellular homeostasis. Mutations in RP1L1, a retina-specific doublecortin (DC) domain protein, cause inherited retinal disorders including occult macular…

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