Journal of cell science
Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity.
Samantha Bunner, Katie Huang, Anish Shah, Schuyler Figueroa, Nick Lang, Catherine Chu, Nebiyat Eskndir, Mai Pho, Gianna Manning, Mindy Zheng, Lilian Fritz-Laylin, Katrina B Velle, Joshua Marcus, James Orth, Andrew D Stephens
Published: 202610.1242/jcs.264118
Abstract
The structural integrity of the nucleus is dependent on nuclear mechanical elements of chromatin and lamins to resist antagonistic actin cytoskeleton forces. Force imbalance results in nuclear blebbing, rupture, and cellular dysfunction found in many…
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