Journal of cell sciencetrans-Golgi NetworkCopper-Transporting ATPasesProtein TransportHumansCopper
Conserved inter-domain interactions drive trans-Golgi network localization and trafficking of homologous copper-ATPases.
Sharon M Jose, Saptarshi Maji, Mrittika Paul, Chirag Singhal, Sreeramaiah N Gangappa, Aayatti Mallick Gupta, Arnab Gupta
Published: 202610.1242/jcs.264111
Abstract
Polytopic copper (Cu)-ATPases are central regulators of the essential micronutrient copper in all organisms. In polarized epithelia, the vertebrate homologues ATP7A and ATP7B undergo copper-induced trafficking from the trans-Golgi network (TGN) to ba…
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