Journal of cell scienceAnimalsHumansMuscle DevelopmentDrosophila ProteinsDrosophila melanogaster
Distinct impacts of human co-chaperone UNC45 paralogs on Drosophila muscle development and function.
Daniel A Smith, Morgan I Mullens, Raul Ramos, Girish C Melkani, Sanford I Bernstein
Published: 202510.1242/jcs.263919
Abstract
Uncoordinated-45 (UNC45) is a conserved protein required for myosin accumulation during muscle development. Invertebrates have one unc-45 gene whereas vertebrates have two paralogs, UNC45A and UNC45B, which exhibit different expression patterns. We u…
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