Development (Cambridge, England)Induced Pluripotent Stem CellsAlzheimer DiseaseHumansDNA MethylationNeurons
Epigenomic alterations and neural development anomalies in induced pluripotent stem cells from sporadic Alzheimer's disease.
Alisar Katbe, Roy Hanna, Anthony Flamier, Dounya Serhani, Rimi Hamam, Andrea Barabino, Erika Tavares, Élise Héon, Gilbert Bernier
Published: 202610.1242/dev.204910
Abstract
Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) resets the aging clock. However, primed iPSCs can retain cell-of-origin epigenomic marks, especially those linked to heterochromatin. Here, we show that iPSCs produced f…
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