Development (Cambridge, England)
An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation.
Gareth Moore, Raluca Revici, Lauren Forbes Beadle, Catherine Sutcliffe, Holly Birchenough, Clair Baldock, Hilary L Ashe
Published: 202610.1242/dev.204584
Abstract
During dorsoventral patterning of bilaterian embryos, the conserved regulator Twisted gastrulation (Tsg) modulates BMP signalling by binding Chordin/Short gastrulation (Sog). Here we elucidate the mechanism by which Tsg interacts with Sog/Chordin to…
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