AAPS PharmSciTechFamotidineTabletsDelayed-Action PreparationsSolubilityDrug Liberation
Fabrication of Gastroretentive and Extended-Release Famotidine Floating Tablets via Fused Deposition Modeling.
Esraa Al Shawakri, Eman A Ashour, Rasha M Elkanayati, Mashan Almutairi, Sundus Omari, Nouf AlShammari, Michael A Repka
Published: 202510.1208/s12249-025-03237-x
Abstract
Famotidine suffers from low oral bioavailability due to poor aqueous solubility, short half-life, and limited gastric retention. This study aimed to develop gastro-retentive floating tablets of famotidine using hot-melt extrusion (HME) and fused depo…
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