AAPS PharmSciTechGefitinibCarcinomaNon-Small-Cell LungPolyethylene GlycolsLiposomes
Enhanced Tumor Treatment Outcomes of PEGylated Liposomal Gefitinib in Non-Small Cell Lung Cancer: A Comprehensive Preclinical Evaluation with Superior Therapeutic Efficacy.
Rajeshkumar S Palva, Jolly R Parikh, Rajnikant M Suthar, Musaratafrin Saiyed, Mitali Patel, Prajesh Prajapati, Umang H Shah
Published: 202510.1208/s12249-025-03235-z
Abstract
This study developed PEGylated liposomal gefitinib (GTL) to overcome clinical limitations of gefitinib therapy in NSCLC, including poor tumor targeting and suboptimal therapeutic outcomes. GTL was formulated using DPPC:cholesterol:mPEG-2000-DSPE (8:7…
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