The AAPS journalAntibody-Dependent Cell CytotoxicityHumansTrastuzumabSignal TransductionCetuximab
Impacts of Antibody Structure and Mixtures on Receptor Signaling for Antibody-Dependent Cellular Cytotoxicity.
Jiakun Guan, Tiexin Wang, Peter M Tessier, Greg M Thurber
Published: 202510.1208/s12248-025-01183-x
Abstract
Antibody-Dependent Cellular Cytotoxicity (ADCC) is a key mechanism of action for humoral immune response, which is important for clinical antibodies such as trastuzumab and cetuximab. The level of ADCC is dependent on multiple properties such as anti…
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