The AAPS journalHumansRetrospective StudiesCytokine Release SyndromeAntibodiesBispecific
Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis.
Apolline Lefèvre, Zinnia P Parra-Guillen, Iñaki F Trocóniz, Christophe Boetsch, Nicolas Frances
Published: 202510.1208/s12248-025-01177-9
Abstract
While T-cell Bispecifics (TCBs) are promising molecules for cancer treatment, their clinical development remains challenging due to Cytokine Release Syndrome (CRS). There is currently no method to accurately predict the doses expected to trigger CRS…
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