The AAPS journalBiomarkersHumansCalibrationReproducibility of ResultsBiological Assay
Best practices in the application of parallelism for biomarker assay validation.
Lindsay King, John Allinson, Lakshmi Amaravadi, Robert Kernstock, Fabio Garofolo, Michele Gunsior, Barry Jones, Joel Mathews, Robert Neely, Robert Nelson, Marc-Olivier Pepin, Honglue Shen, Lauren Stevenson, Troy Voelker
Published: 202610.1208/s12248-025-01176-w
Abstract
An assessment of parallelism is critical for biomarker assays to confirm whether the assay recognizes the endogenous analyte similarly to the calibrator, the suitability of a surrogate calibrator matrix and the potential need for a minimal required d…
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