The AAPS journalReceptorsFcHistocompatibility Antigens Class IHumansTranscytosis
The Impact of Cognate Antigen Binding on the FcRn-mediated Transcytosis and Recycling of Monoclonal Antibodies.
Sharon Vijayanand, H A Daniel Lagasse, Million A Tegenge, Zuben E Sauna, Basil Golding
Published: 202510.1208/s12248-025-01174-y
Abstract
Immunoglobulin G (IgG) antibodies rely on neonatal Fc receptor (FcRn)-mediated recycling and transcytosis for prolonged serum half-life and tissue distribution. However, high antigen loads during infection may alter FcRn-mediated trafficking, impacti…
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