The AAPS journalHumansAntibodiesMonoclonalHumanizedCOVID-19 Drug Treatment
Association of Immunogenicity and Drug Exposure and the Importance of Target Engagement in ADA Development: A Clinical Case Study of Anti-SARS-CoV-2 Biotherapeutics.
Susan C Irvin, Samit Ganguly, Zhiqiang Wang, Zhongqing Will He, Marguerite Alejandro, Kaitlin Donohue, Chinnasamy Elango, Chris Gallo, Stephen Guttmann, Shawn Kalicharan, Kristina Kameron, James Laird, Kevin Laurino, Hailey Trotter, Jacqueline Rodriguez
Published: 202510.1208/s12248-025-01152-4
Abstract
The administration of therapeutic proteins, such as monoclonal antibodies (mAbs) may result in the formation of anti-drug antibodies (ADA), but there is limited publicly available data for biotherapeutics with exogenous targets or with targets in low…
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