The AAPS journalCyclic AMPIncretinsHumansAntibodiesNeutralizing
Affinity Capture Elution Coupled with Cell-based Cyclic Adenosine Monophosphate Assay as a Platform Method for Detection of Neutralizing Antibodies to Incretin Molecules.
Nichole A Reynolds, Yan Q Chen, Richard E Higgs, Boris Calderon, Jeff W Cramer, Nicoletta Bivi, Michael E Hodsdon, Heather A Bullock, Travis E Shockley, Victoria L Peek, Justin K Mack, Deven Lemen, Victoria Copeland, Andrea Ferrante, Robert J Konrad
Published: 202510.1208/s12248-025-01143-5
Abstract
Formation of anti-drug antibodies (ADA) and, in particular, neutralizing antibodies (NAb), is a major risk to the development of biotherapeutics. Cell-based assays, which can reflect the mechanistic interactions among the drug, target, and NAb, are o…
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