The AAPS journalHumansModelsBiologicalHydroxymethylglutaryl-CoA Reductase InhibitorsDrug Development
Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications.
Luna Prieto Garcia, Pär Nordell, Christine Ahlström, Hans Lennernäs, Erik Sjögren
Published: 202510.1208/s12248-025-01137-3
Abstract
The conventional strategy of prescribing the same dosage to all patients can result in suboptimal efficacy and safety. This is particularly true when considering drug-gene interactions (DGIs), drug-drug interactions (DDIs), or in individuals with com…
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