The AAPS journalMicellesTacrolimusPhenolsOphthalmic SolutionsChemistry
Investigation of 2,4 Di-tert-butylphenol Leaching from Multidose Ophthalmic Devices into Tacrolimus Micellar Formulations.
Marion Barrieu, Philip Chennell, Bénédicte Mailhot-Jensen, Valérie Sautou
Published: 202510.1208/s12248-025-01124-8
Abstract
Short contacts between medical devices and medications that they contain can cause drug sorption or leaching of unwanted compounds which can have clinical consequences. However, the parameters that govern these interactions are still incompletely und…
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