Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy (I-PREDICT) N-of-1 Precision Oncology Study: Molecular Profiling to Match Individually Dosed, Personalized Drug Combinations.
Jason K Sicklick, Daisuke Nishizaki, Hirotaka Miyashita, Ryosuke Okamura, Michael E Hahn, Mina Nikanjam, Paul T Fanta, David E Piccioni, Hitendra Patel, Ramez N Eskander, Rana R McKay, Jeffrey S Ross, J Jack Lee, Scott M Lippman, Shumei Kato
Published: 202610.1200/JCO-25-01453
Abstract
PURPOSE: Malignancies have complex and distinct molecular profiles that may not segregate by tumor type. However, most precision oncology treatments are matched to a single biomarker. We aimed to optimize therapy for advanced cancers using individual…
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