The British journal of psychiatry : the journal of mental science
Estimating the smallest worthwhile difference of recommended psychotherapies for depression: observational study.
Ethan Sahker, Yan Luo, Kenji Omae, Aran Tajika, Manuela L Ferreira, Astrid Chevance, Stefan Leucht, Sarah Markham, Roger Ede, Andrea Cipriani, Georgia Salanti, Toshi A Furukawa
Published: 202510.1192/bjp.2025.10453
Abstract
BACKGROUND: The smallest worthwhile difference (SWD) represents the smallest beneficial effect of an intervention that patients deem worthwhile given the harms, expenses and inconveniences of the intervention. The SWD facilitates interpretation of th…
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