Journal of intensive care
Exploratory characterization of dynamic soluble programmed death-ligand 1 trajectories and their association with mortality in critical coronavirus disease 2019.
Shungo Takeuchi, Eiji Kawamoto, Takashi Matsusaki, Daisuke Ono, Yosuke Sakakura, Arong Gaowa, Eun Jeong Park, Motomu Shimaoka, Ryuji Kaku
Published: 202610.1186/s40560-025-00846-3
Abstract
BACKGROUND: Persistent immune checkpoint activation is a recognized feature of critical coronavirus disease 2019 (COVID-19). However, the temporal behavior and clinical utility of soluble programmed death-ligand 1 (sPD-L1) remain unclear. We investig…
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