European journal of medical research
GLP-1 agonists reduce right ventricular mitochondrial dysfunction by inhibiting the GSK3β-Drp1 signalling in pulmonary hypertension.
Lin Zhao, Yanghong Liu, Ziwei Ou, Xiexiong Zhao, Wen Zhang, Tangzhiming Li, Zhe Sheng, Ye Chen, Hui Luo
Published: 202610.1186/s40001-025-03815-6
Abstract
Right ventricular (RV) dysfunction is a critical complication of pulmonary hypertension (PH) with limited treatment strategies. This study evaluated the therapeutic efficacy of the GLP-1 agonist semaglutide on RV dysfunction in rodent PH models, focu…
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