European journal of medical research
High glucose induces osteoblasts ferroptosis via the TXNIP/Trx-1/GPX4 pathway in type 2 diabetic osteoporosis.
Yantao Zhao, Di Xiao, Miao Zeng, Yijie Gao, Anquan Huang, Changle Ren, Yunxia Du
Published: 202510.1186/s40001-025-03749-z
Abstract
Type 2 diabetic osteoporosis (T2DOP) is characterized by impaired bone formation and increased fracture susceptibility; however, the molecular mechanisms linking hyperglycemia to osteoblast dysfunction remain insufficiently defined. In this study, we…
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