European journal of medical research
BRCA1 alleviates inflammation, oxidative stress, and ovarian granulosa cell apoptosis by inhibiting endoplasmic reticulum stress, thereby ameliorating polycystic ovary syndrome.
Xiaolan Huang, Shuyin Zhang, Danhong Liang, Lingling Qiu, Ruiyun Wu, Rong Wei, Xiaoqing Chen, Suzhen Huang
Published: 202610.1186/s40001-025-03734-6
Abstract
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by metabolic imbalance, oxidative stress, and granulosa cell (GC) dysfunction. Given the established role of BRCA1 in maintaining genomic stability and regulating stress…
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