Effect of clinical pharmacist's intervention on perioperative prophylaxis of antimicrobial drugs in AIDS patients.

OBJECTIVE: This study aimed to evaluate the effect of clinical pharmacists' intervention using perioperative special prescription review mode on the preventive use of perioperative antimicrobial drug in Acquired Immunodeficiency Syndrome (AIDS) patients with clean incision surgery in the First hospital of Changsha. MATERIALS AND METHODS: With reference to the latest guidelines and expert consensus worldwide, the National Health Commission's guiding principles for the clinical application of antimicrobial drugs were used as the basis for review. The perioperative antimicrobial drug review criteria were formulated, and the special prescription review model was established by combination of administrative interventions and other measures. Sampling was conducted according to the type of surgery, and 109 AIDS patients with clean incision surgery in our hospital from January 2020 to June 2021 were grouped into the control group, and 110 HIV patients with clean incision surgery who received the clinical pharmacists' intervention from July 2021 to December 2022 were categorized into the intervention group. Perioperative antimicrobial drug use and hospitalization-related indexes were compared between the two groups. RESULTS: After the intervention of clinical pharmacists, there was a significant decrease on the rate of unreasonable perioperative prophylactic use of antimicrobial drugs in AIDS patients with clean incision. A significant reduction was also seen in the length of hospitalization, Defined Daily Doses (DDD) of antibacterial drugs, cost of antibiotics, and duration of preventive use of antibiotics. CONCLUSION: For surgical AIDS patients, the intervention of clinical pharmacists contributes to enhancing the rationality of antimicrobial drug use, and reducing the hospitalization cost of patients during the perioperative period of clean incision.