Cell & bioscience
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface.
Sujuan Li, Yichi Wu, Yuan Gao, Anran Tian, Minglan Yao, Fucheng Meng, Furong Liang, Yingying Li, Cai Zhang, Xiaoping Luo
Published: 202610.1186/s13578-025-01529-0
Abstract
Maternal hyperhomocysteinemia (HHcy) is closely linked to fetal growth restriction (FGR), yet the underlying mechanisms remain incompletely understood. In this study, we established a rat model of HHcy by administering a high-methionine diet during p…
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