Cell & bioscience
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
Zeping Chen, Senlin Zhao, Desheng Chen, Yichao Lou, Hanhao Lu, Qihang Yao, Jie Lu, Hongcheng Sun
Published: 202610.1186/s13578-025-01524-5
Abstract
BACKGROUND: Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis. However, the mechanisms underlying KLF4 loss in human HCC are poorl…
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