Cell & bioscience
ZMIZ2 interacts with PIN1 to promote lung adenocarcinoma EMT and metastasis via activation of the PI3K/AKT pathway.
Zhiyue Su, Yuhong Wang, Ersuo Jin, Feifei Wang, Weiwei Zhang, Yingxi Zhang, Zeyi Liu, Shengjie Wang, Hongli Yang, Chang Qi, DongMei Gu, Xia Liu, Lingchuan Guo, Hong-Tao Zhang, Zhe Lei
Published: 202510.1186/s13578-025-01522-7
Abstract
ZMIZ2, a transcription co-activator, is frequently overexpressed in various tumors. However, its functional role and molecular mechanisms in driving non-small cell lung cancer (NSCLC) metastasis remain elusive. Our study reveals that ZMIZ2 is signifi…
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