Stem cell research & therapy
Klotho protects the osteogenic function of human periodontal ligament stem cells in periodontitis by inhibiting NOX4-mediated ferroptosis.
Chuanmiao Lin, Junbin Wei, Tingting Zhao, Lingling Chen, Shuxuan Rong, Junkun Zhan, Wenjia Lai, Yan Wang, Yunyi Xie, Huan Chen
Published: 202610.1186/s13287-026-04894-w
Abstract
BACKGROUND: Periodontitis, the leading cause of tooth loss worldwide, is closely linked to the compromised regenerative capacity of human periodontal ligament stem cells (hPDLSCs). Stem cell-based tissue engineering is a promising treatment for perio…
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