Stem cell research & therapyDiabetic RetinopathyEndoplasmic Reticulum StressAnimalsMesenchymal Stem CellsHumans
Intravenous delivery of mesenchymal stromal cells reverses Müller cell endoplasmic reticulum stress in diabetic retinopathy.
Wei Yan, Ruiyun Guo, Tong Liu, Yukun Liu, Rui Ping, Boxin Liu, Jingjing He, Matthew D Griffin, Seán O Hynes, Sanbing Shen, Yan Liu, Jun Ma, Timothy O'Brien
Published: 202510.1186/s13287-025-04876-4
Abstract
BACKGROUND: Mesenchymal stromal cells (MSCs) have emerged as a promising disease-modifying therapy for the complications of diabetes mellitus (DM), including diabetic retinopathy (DR). However, the optimal treatment regimen remains unclear, and chall…
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