Stem cell research & therapy
In0testinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD.
Brinda Balasubramanian, Shivam Patel, Louis Gall, Nick Hannan, William Dalleywater, Joerg Huelsken, Carmen Pin, Gordon W Moran, Paloma Ordóñez-Morán
Published: 202510.1186/s13287-025-04872-8
Abstract
BACKGROUND: Intestinal epithelial stem cells (SCs) and their transit-amplifying (TA) progeny are critical for mucosal repair and regeneration. However, their behaviour under chronic inflammatory conditions, such as those observed in Inflammatory Bowe…
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