Clinical epigenetics
Epigenomic subtypes and prognostic methylation signatures in clear cell renal cell carcinoma.
Laura Iisager, Cecilie Lindgaard, Johanne Ahrenfeldt, Jesper Jespersen, Karoline Kondrup, Laura Zanini, Anna K Keller, Line Raaby, Mie G Thorlund, Karina D Sørensen, Niels Fristrup, Iben Lyskjær
Published: 202610.1186/s13148-026-02055-7
Abstract
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is characterized by marked epigenetic dysregulation, contributing to aberrant gene expression and tumor progression. To expand current knowledge on genome-wide methylation patterns in ccRCC, we perf…
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