The impact of initiating SGLT2 inhibitors on eGFR: a pilot study at a secondary hospital in Malaysia.

OBJECTIVE: The purpose of this study was to evaluate the effect of sodium-glucose cotransporter 2 inhibitors on estimated glomerular filtration rate and serum creatinine among patients with type 2 diabetes mellitus and chronic kidney disease receiving treatment in a secondary hospital in Malaysia. The study also examined changes in blood glucose control following treatment. This work represents real-world data generated from routine clinical practice rather than from a controlled trial. RESULTS: A total of 76 patients were included. Serum creatinine showed a mild rise at three months after treatment initiation and subsequently stabilised at six and twelve months. Estimated glomerular filtration rate declined over one year, but the reduction was modest and remained below ten per cent. Blood glucose control improved, with mean glycated haemoglobin decreasing from baseline to the three-month assessment and remaining stable thereafter. No meaningful association was observed between changes in glycated haemoglobin and kidney function throughout the follow-up period. Overall, the findings indicate that kidney function stabilised after the early phase of treatment and that blood glucose levels improved following the introduction of sodium-glucose cotransporter 2 inhibitors.