Arthritis research & therapy
Inhibition of NOX4 attenuates muscle damage and mitochondrial dysfunction in inflammatory myopathy.
Hae Rim Kang, Jeong Yeon Kim, Seon Uk Kim, Hee Sung Kwon, Seo Yoon Ban, Min-Gang Kim, Jae Hyun Moon, Eun Young Lee
Published: 202510.1186/s13075-025-03705-6
Abstract
BACKGROUND: Idiopathic inflammatory myopathy (IIM) is a chronic autoimmune disorder characterized by muscle inflammation and weakness. If a muscle is already damaged, muscle strength often fails to restore with current treatments. Although, NADPH oxi…
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