Trials
Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study).
Nicolas Grillot, Christelle Volteau, Pauline Quillet, Xavier Ambrosi, Anaïs Caillard, Jean-Stéphane David, Alice Blet, Pierre Bouzat, Laurent Blanchet, Nathalie Bruneau, Nidhal Chebbi, Quentin Saint-Genis, Samy Figueiredo, Pierre-Grégoire Guinot, Alexandre Joosten
Published: 202610.1186/s13063-026-09452-6
Abstract
BACKGROUND: Propofol is the most frequently used hypnotic during rapid sequence induction in patients at risk of pulmonary aspiration of gastric contents worldwide. Its most common side effect is to induce hypotension due to dose-dependent vasoplegia…
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