HGMT: a database of human gut microbiota for tumors and immunotherapy response.
Jinxin Liu, Mingyu Wang, Chentao Xu, Longhao Jia, Senying Lai, Zi-Chao Zhang, Jinglong Zhang, Wei-Hua Chen, Yucheng T Yang, Xing-Ming Zhao
Abstract
Open AccessHGMT is a database designed to analyze, explore, and visualize gut microbiomes from diverse tumor types. We process metagenomic datasets from 18,630 stool samples across 37 tumor types, including 2,207 samples from immunotherapy-treated patients across 12 tumor types. HGMT provides an interactive portal for querying taxonomic and functional profiles, visualizing cross-dataset differential abundance taxa in tumors, and identifying their pan-tumor associations. Our analysis reveals the capability of gut microbiota in diagnosing gastrointestinal tumors and predicting immunotherapy response for non-small cell lung carcinoma. HGMT represents a valuable resource for investigating the roles of gut microbiota in tumors and immunotherapy response.