Genome biology
BASCULE: bayesian inference and clustering of mutational signatures leveraging biological priors.
Elena Buscaroli, Azad Sadr, Riccardo Bergamin, Salvatore Milite, Edith Natalia Villegas Garcia, Arianna Tasciotti, Alessio Ansuini, Daniele Ramazzotti, Nicola Calonaci, Giulio Caravagna
Published: 202510.1186/s13059-025-03835-9
Abstract
Mutational signatures provide key insights into cancer mutational processes, but the availability of signature catalogues generated by different groups using distinct methodologies underscores a need for standardization. We introduce a Bayesian frame…
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