Molecular brainHumansDopaminergic NeuronsOrganoidsMitochondriaMesencephalon
Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons.
Akihiko Nishijima, Mutsumi Yokota, Soichiro Kakuta, Akihiro Yamaguchi, Kei-Ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Nobutaka Hattori, Masato Koike
Published: 202510.1186/s13041-025-01268-w
Abstract
Mitochondrial dysfunction and abnormalities in mitochondrial quality control contribute to the development of neurodegenerative diseases. Parkinson's disease is a neurodegenerative disease that causes motor problems mainly due to the loss of dopamine…
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