Journal of translational medicine
Activation of NF-κB signaling pathway in GSDME-low esophageal squamous cell carcinoma cells enhances radioresistance.
Lingli Lei, Yi Zhao, Bing Wang, Minghui Chang, Renya Zeng, Zhe Yang
Published: 202610.1186/s12967-025-07635-4
Abstract
BACKGROUND: Radioresistance in esophageal squamous cell carcinoma (ESCC) contributes to locoregional recurrence and radiotherapy failure. Radiotherapy has been demonstrated to induce Gasdermin E (GSDME)-mediated pyroptosis. This study aims to identif…
Preview only. Read the full abstract at the source