Journal of translational medicine
Verteporfin, an inhibitor of nuclear YAP, improved multi-ciliated cell differentiation in the airway epithelium.
Ryosuke Nakamura, Yo Kishimoto, Tomoko Kita, Susumu Yoshie, Shinji Kaba, Yukiko Okuno, Koichi Omori
Published: 202510.1186/s12967-025-07250-3
Abstract
BACKGROUND: Impaired multi-ciliated cell (MCC) differentiation, observed in various airway diseases, causes prolonged inflammation and further airway complications due to malfunction of the airway defense mechanism. YAP/TAZ-TEAD signaling mediates mu…
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